Microbes: Their Diversity, Antibacterial Targets and Mechanisms of Antibiotic Resistance
by Dr. Arthur E. Girard
Principal Research Investigator,
Infectious Disease Sections
Pfizer Central Research
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Where are microbes found? They can be located in many places including extreme environments. Microbes are very durable and capable of withstanding a wide variety of temperatures and have adapted to different locales.
Microbes are developing resistance to antibiotics. Antibiotics work to defeat microbes in different ways and bacteria defend themselves using different mechanisms. The pharmaceutical industry has the task of targeting the most resistant microbes and developing agents that are safe and effective in controlling these organisms.
Guidelines have been developed to prevent the spread of resistance and resistant organisms. Some techniques are easily implemented and can be immediately put into action by hospitals and laboratories. Individuals can help prevent the development of resistance by not requesting antibiotics for illnesses caused by viruses and by completing the prescribed course of antibiotics when used.
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