Meet the Current Teaching Team
Team Profiles: Allergies
The Teaching Team for Allergies consists of three Genentech scientists:
Paula M. Jardieu received her Ph.D. in microbiology
from Michigan State University in 1982 studying the effects of zinc
deficiency on immune function of antibody secreting cells. She
received a post-doctoral fellowship from 1982 to 1985 to study the
regulation of IgE synthesis with Dr. Kimishige Ishizaka in the
Department of Immunology at Johns Hopkins University School of
Medicine. Dr Ishizaka is one of the founding fathers of IgE biology.
Paula studied the activity of IgE binding proteins which regulate IgE
glycosylation and biological activity. Paula came to Genentech in
1986 hoping to purify and clone these binding proteins to determine if
they could be used to inhibit the biological activity of IgE.
Although her lab's attempts to clone the IgE binding proteins were
unsuccessful she decided to approach the problem of inhibiting IgE
biological activity from a different angle. Her decision to develop a
antibody that blocks IgE binding to the IgE receptor on mast cells led
to the development of a drug that is currently in Phase II trials with
the FDA.
Paula is currently a staff scientist in the Immunology Department and
is the senior project leader for both the anti-IgE and anti-LFA
antibody projects. Paula has participated in several bay area
symposia on the role of women in science. When she is not in the lab
she is either on the tennis court or attending a rare antiques
auction.
Robert Shields is a senior research associate in the
Immunology Department at Genentech who joined Paula's lab in 1988 to
help with the purification of IgE binding proteins.
"Prior to coming to Genentech I worked in both the Department of
Immunology and Cardiovascular Research Institute at the U.C. San
Francisco School of Medicine studying the biochemistry of T cell
receptors signaling and the role of IgE in animal models of allergic
asthma. I have a strong vested interest in developing new therapies
for the treatment of allergy and asthma since I am asthmatic and have
allergies to shellfish, animal dander, molds and most western grass
pollens.
"My interest in biology dates back to my high school field trips to the
Mohave desert in Southern California where we studied the ecology of
kangaroo rats. My interest in research started as an undergraduate at
Stanford wandering through the mud flats of Pescadero Estuary in San
Mateo county collecting samples for fecal coliform bacteria counts as
part of an independent research project in marine biology. When I am
not helping my wife with activities revolving around our three
daughters ages 7, 4 and 2, I go down to Monterey Bay for some scuba
diving and underwater photography. My awareness of the public school
system's need for more science education resources has grown since I
started participating in my oldest daughters annual science fair
projects."
Gerald Nakamura is a senior research associate in the
immunology Department at Genentech Inc.
"My first introduction to research was during the year I spent as a
volunteer in a Human Genetics laboratory while an undergraduate at the
University of California at Berkeley. Although my scientific
contribution to the lab was probably minimal, it was a wonderful
experience for me and I will always be grateful to that professor for
the opportunity. After I graduated with a degree in Physiology, I did
an internship in a Cardiovascular Research lab at the U.S. Public
Health Service Hospital in San Francisco and then worked as a clinical
chemist in a commercial diagnostic lab. About 13 years ago, I came to
Genentech to work on the development of a Hepatitis B vaccine and to
learn how to do good science. For the past 10 years, I have working
on the development of an HIV vaccine focusing on the identification of
regions on the virus critical for receptor recognition and antibody
neutralization.
"I have been married for 12 years and I have a 10 year old daughter and
a 7 year old son. In addition to our daily routine of helping the
kids with their homework, reminding them to practice their music
lessons and helping them to become better soccer players, we also
enjoy hiking, camping, biking and skiing. Ten years ago I became
interested in Bonsai and started collecting Japanese maples. I now
have a small manageable collection of uncommon maples. Shortly after
I came to Genentech I began taking violin lessons. Having no prior
formal training in music, a lack of any natural rhythm and an ear that
could barely distinguish a sharp from a flat, has made the first 11
years of instruction challenging. Fortunately, I have a patient music
instructor who teaches with the same enthusiasm and spirit I found in
many of the AE fellows I met at the 1994 summit."
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